The best weight-loss drug approved by the FDA: Semaglutide, both hypoglycemic and weight-loss, good news for obese people

At present, there are about 2 billion obese patients in the world, among which, there are more than 90 million obese patients in China, and about 2.8 million people die of obesity every year. Obesity has become a disease that endangers public health. Excessive obesity can increase the incidence of type II diabetes , induce three highs, liver cirrhosis and other chronic diseases, and seriously shorten life expectancy.



For obesity treatment, interventions from diet and exercise can be used as adjuvant therapy, but most obese patients find it difficult to persist. Therefore, if the weight has been seriously exceeded, drug therapy can obtain more effective and stable weight loss effect . However, in the slimming drug market, the drugs are uneven, and most of them have the problems of large side effects and failure to achieve the desired effect.

Thanks to the continuous improvement of medical drug research and development technology, the new fat-reducing drug " Semaglutide " developed by Novo Nordisk has been approved by the US Food and Drug Administration. It can be used as a treatment drug for type II diabetes and obesity , allowing more Many patients see a new dawn.

The drug is a receptor agonist, and its main substance is glucagon-like peptide , which can increase satiety, reduce calories, and help reduce weight. Compared with the previous anti-sugar and fat-reducing drugs, the drug has a longer half-life and can stay in the body for a long time, so it can be used once a week.



The drug can effectively reduce the weight of obese patients and II diabetic patients. A phase III clinical follow-up data shows that injecting 2.4 mg of the drug every week can effectively reduce the appetite of obese patients. As early as 2020, in the control group of the I clinical trial of the drug, the effect of taking semaglutide and placebo was evaluated. In the way of life intervention, the drug was injected according to the amount at the same time, and the lipid-lowering effect in the semaglutide group Better than the placebo group, therefore, can suggest the effectiveness of semaglutide.



In the phase 1 clinical trial, a total of 16 countries and regions were selected for single-blind or double-blind clinical trial comparison. Let obese and diabetic patients lose weight through various life interventions, but do not give semaglutide drug support, another group uses semaglutide, the results show that life interventions did not successfully reduce weight, but semaglutide The Maglutide treatment group successfully reduced body weight.

Another group is a controlled trial, which compares the semaglutide treatment group with the placebo treatment group, and both groups receive life intervention treatment. The main purpose is to evaluate whether semaglutide has weight loss effectiveness, and the ultimate goal is to drop the body weight to 5%.



★ Important clinical significance for the treatment of obesity

The results showed that about 86% of patients in the semaglutide treatment group reached their target weight, that is, they lost 5% of their original weight, and the average body weight base of the whole group was lower than 14.9% of the placebo treatment group. Keeping the patient's body fat at a normal level is very important for weight-loss drugs , because most weight-loss drugs consume a lot of body fat in order to reduce body fat in order to reduce body fat. This way of weight loss will lead to endocrine Disorders are very harmful to the health of the body. However, semaglutide can not only reduce weight, but also maintain a certain amount of fat, suggesting that the drug is safe and effective.

In addition, the semaglutide treatment group was undergoing life intervention, that is, reducing calorie intake by 500 kcal per person per day, and insisted on doing moderate-intensity exercise for more than 30 minutes every day, all of which showed faster and more stable fat consumption, while blood sugar It can also be stabilized . Therefore, the use of semaglutide can effectively treat type II diabetes, which can effectively reduce blood sugar while losing weight, and obtain double benefits. And the administration method of injecting only once a week greatly improves the patient's medication compliance and improves the patient's inconvenience in medication.




★Comparison with other weight loss treatments

Bariatric surgery is a treatment method that can effectively reduce and maintain body weight. However, surgery is an invasive treatment and is extremely invasive. Postoperative rebound may still occur , causing weight to fluctuate. However, most products in weight-loss drugs will have side effects, such as: amphetamine can cause dependence in patients, and there is a high probability of rebound after stopping the drug, so the only way to maintain weight is to take the drug continuously, but it increases the burden on the kidneys ; Lorcaserin has harmful effects on the heart and can cause side effects such as heart poisoning and rapid heart rate; lorcaserin has been recalled many times because it has carcinogenic factors.

However , fat inhibitors such as naltrexone-bupropion and orlistat have high drug safety and can effectively reduce body weight, but they do not have the effect of preventing and treating type II diabetes . Semaglutide can effectively reduce body weight and blood sugar while protecting vascular endothelial cells. Therefore, the drug has more advantages in terms of drug safety, effectiveness and extensiveness.

In the phase 1 clinical trial, about 84.1% of the diabetic patients in the semaglutide treatment group recovered their blood sugar effectively after the trial, while the blood sugar recovery rate of the diabetic patients in the placebo treatment group was 47.8%. The results may suggest that semaglutide has more hypoglycemic effect in high-risk groups . In addition, after taking semaglutide, the blood pressure level, waist circumference, glycosylated hemoglobin and blood lipid levels can all be effectively reduced, suggesting that the drug can obtain the effect of protecting cardiovascular and cerebrovascular.



From the test data of all the control groups, the effectiveness of semaglutide is reflected, and it can effectively lose weight, and it also has the effect of lowering blood sugar. It can be used as a therapeutic drug for type II diabetes patients or patients with obesity. Weight loss is better than other weight loss drugs. In addition, the oral drug of semaglutide is injected once a week, which further improves the patient's medication compliance.

For diabetic patients with obesity, the metabolic mechanism of the body has been abnormal. Therefore, the single use of life intervention can no longer achieve the ideal weight loss effect. Therefore, it is necessary to focus on drug treatment, supplemented by life intervention treatment , and take sufficient amount of medicine. And you should cooperate with the doctor on a regular basis for treatment and medication, and you should not increase the dosage of the medicine privately in order to pursue the effect of weight loss, so as to avoid hypoglycemia or various complications caused by excessive weight loss.



At the same time, we should also start with diet control, keep a light diet , balanced nutrition and health , control calories within a reasonable range, and ensure the body’s metabolic balance . The body's ability to remove blood lipids and oils to achieve effective weight loss and lower blood sugar.

https://www.arshinepharma.com/info/the-best-weight-loss-drug-approved-by-the-fda-77365663.html